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Posts Tagged ‘Biotechnology’

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Update | April 2018
Dear reader,

Through this BioLinX Update we offer those who are not aware yet, the opportunity to still participate in one of our 4 upcoming events. These events are either hosted by BioLinX, or we partner up in organizing them. Join in now! Through, among other things, these events BioLinX has already contributed to the success of well over 500 unique projects and/or companies. 

UPCOMING EVENTS

10-11 April | Finance Academy | Milan, Italy

The 3rd edition of our succesful ‘Finance Academy & Brokerage’ format. After the Netherlands and Sweden, this event now visits Milan. What to expect:

On April 10th , companies attend our free coaching session on ‘VC-pitching’. Experienced coaches from relevant industry areas  prepare presenters for their participation in the Finance Academy the following day.

April 11th, participants present their business projects and network to the audience of experts in innovation, Business Angels, Venture Capitalists, Corporate and Institutional investors and peers and are reviewed by the Expert Jury. Still a few seats left, but please note: registration for the Finance Academy closes on April 6th!!

11 April | Brokerage Event in connection with Finance Academy | Milan, Italy

Federchimica – the Italian Federation of Chemical Industries  and its relevant sectoral associations host BioLinX’s Brokerage event focusing on promising bioeconomy value chains and innovative initiatives exploiting industrial biotechnologies, bio-sourcing raw materials and/or bio-transforming products. Focus on value chains such as cosmetics, detergents and cleaning products, industrial biotech and foodingredients.

For programme and registration: http://www.biolinx-project.eu/event/circular-bioeconomy-workshop-italy

12 April | Webinar on EU’s LIFE Programme| online

BioLInX’ experts inform you on if and how your biobased and environmental-friendly technology, process or product can benefit from EU’s LIFE funding programme. In recent years, the programme has supported a variety of bio-based projects with a funding of up to 60%.

Thursday 12 April 2018, 10:30 – 11:30 hrs CET

During this webinar you will learn more about
·         the LIFE programme
·         the main criteria
·         eligible activities
·         the preparation of a 10-page concept note for the upcoming deadline on 12 June 2018. 

Registration is free of charge. You can register here: http://online.cme24.de/index.php?id=1076

25-26 April | Online Matchmaking

BioLinX Online Brokerage is an innovation exchange and a matchmaking platform serving SMEs, academia and large companies. If you are looking for new business partners, exciting inventions, new products and services or investments, BioLinX will connect you with right people from the European bio-economy community.

Why should you participate? You will save time and costs, avoid unnecessary business trips, meet  experts from all over Europe and make it quick and easy to pinpoint offers and requests.

Register for participation on biolinx.talkb2b.net/members/register

16 May | Pitching & Networking Event| Bratislava, Slovakia

Wondering what the umbrella term bioeconomy means and how it might be  relevant to you? Interested in how innovative ideas in the agrifood sector can take off, reach scale and receive EU funding? Join us at ther pitching and networking event in Bratislava on the 16th May 2018, and find out more about it with leading technology and funding experts.

During the event, you can pitch your company and expertise to bio-experts and benefit from the networking opportunity. The participant delivering the best pitch (chosen by a jury of bio experts) will receive a free EU grant scan service from BioLinX partner, PNO Consultants.

We look forward to meeting you during one of these four events!

 BioLinX?

Would you like more details on what we have to offer and to whom in particular we offer it?

Read our brochure or visit our website!

Kind regards on behalf of the BioLinX Consortium,

Dennis van der Pas (coordinator BioLinX)
d.vanderpas@rewin.nl

 

BioLinX Project provides links to commercialize your innovative idea

www.BioLinX-project.eu

     @BioLinXproject

BioLinX is a H2020 project, with the goal to support H2020 and FP7 projects in commercializing their innovative ideas and to connect them to new regional networks and markets. This project has received funding from the European Union’s Horizon 2020 research and innovationprogramme under grant agreement No 65269.                                                                                                         

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Biotechnologists and chemical engineers work closely together in many fields. One of them is industrial („white“) biotechnology. Metabolic engineering offers many opportunities for using biotechnological processes.

Whoever has ever dealt with organic synthesis probably experienced that special moment between total frustration and unbelieving awe when encountering biochemistry for the first time: An enzyme with an enigmatic abbreviation is introduced, and functionalizations are performed in exactly the right places with exactly the desired stereochemistry in one step where a conventional synthesis with 17 steps was otherwise required. No wonder microorganisms have taken root as little helpers in industrial processes. But nature with its microbes and enzymes does not always exactly meet the chemist’s or pharmacist’s wishes.

What is there to do? So far, organisms have been variegated based on haphazard mutations and optimized using trial-and-error-processes until a bacterium had been found that was able to grow and be cultivated and produced the desired substance with acceptable yield. This development can take decades, is expensive, and the result is not necessary a real optimum.

That’s where metabolic engineering enters the stage. The basic idea: If the metabolism of a microbe is understood well enough, an organism can be designed that does exactly what it is supposed to do. Design wins over mutation.

Unfortunately, adjusting only one screw – meaning one gene – usually does not work. Metabolic processes interact in a very complex way, and optimizing an organism requires to take the whole metabolism into account. In order to achieve this, a couple of methods are available: It is now possible, for example, to isolate a single cell and study its metabolism instead of working with the mean of a large population. Mathematical and statistical simulation models also contribute in identifying the places where genetic manipulation can work.

In addition, there exist several approaches to reduce the complexity of the cellular system.

Of course you cannot build walls inside a cell or isolate parts from each other as you would do in a mechanical plant and still have a living cell. A variety of methods can be used to achieve orthogonalization, or the decoupling of metabolic processes. One strategy consists of the development of bacteria with minimal equipment; Craig Venter’s “artificial cell” that drew attention a couple of months ago represents this line of thinking. Another interesting approach is to use cell-free in vitro systems. They combine the advantages of in vivo and in vitro systems. First, a cell with the wanted enzyme system is developed. This cell is then broken down and homogenized before unwanted enzymes are removed. This can be done by introducing cutting sites into the enzymes while the cell grows. These cutting sites are designed for specific protein-cutting enzymes, so-called proteases, that cannot access the other wanted enzymes. The protease is then added to the processed in vitro system. The unwanted enzymes are split, while the desired enzymes remain.

Some processes based on „designer-cells“ are already competitive, but overall, metabolic engineering makes its way only slowly into large industrial production processes. This is due to the large and time-consuming testing and to the often incomplete knowledge of the detailed metabolism of the organisms used.

But scientists from industry and research institution are working hard to identify interesting chemical building blocks and train microorganisms to produce them. Thus, this kind of “talent shortage” could soon be history.

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From September 25-29th, 2o11, the 8. European Cogress of Chemical Engineering and the 1st European Congress of Applied Biotechnology will take place in Berlin, Germany. In the run-up to the most important event for the European scientific and industrial communities in these fields, this blog will inform you about the latest news regarding preparations, organizational issues and, of course, the major topics of the conferences as well as news and articles on chemical engineering and biotechnology in general.

If you have any questions or suggestions, you are welcome to post your comments!

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